Across TCGA patient cohorts, GTF2H4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2H4-associated genes across cancer lineages are eEF2, A-Raf_pS299, and JNK_pT183_Y185. Each is linked with GTF2H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2H4-to-partner and partner-to-GTF2H4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H4→partner) and Y-score (partner→GTF2H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.419	+2.321	.019	.035	3	2
UCEC	A-Raf_pS299 →	-0.160	-2.999	.007	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.180	-3.446	.033	.005	3	1
UCEC	JNK2 →	+0.345	+2.321	<.001	.035	3	1
UCEC	Ku80 →	+0.318	+3.472	.007	.002	3	1
UCEC	MEK1 →	+0.508	+3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

GTF2H4 survival (RNA) · tumor vs normal (RNA) · all GTF2H4 data types