GTF2H1

Across TCGA patient cohorts, GTF2H1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2H1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with GTF2H1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2H1-to-partner and partner-to-GTF2H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GTF2H1-low versus GTF2H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H1→partner) and Y-score (partner→GTF2H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.109	-2.780	.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.103	-2.115	.011	.017	3	1
UCEC	ERK2 →	+0.144	+2.115	.028	.016	3	1
UCEC	Heregulin →	-0.086	-1.514	.040	.015	3	1
UCEC	IGFBP2 →	-0.458	-1.247	.038	.045	3	1
UCEC	JNK2 →	+0.230	+2.137	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by GTF2H1 expression — UCEC

Explore this box plot interactively →