Across TCGA cell cohorts, GTF2F2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2F2-associated genes across cancer lineages are COX6A2, SPIC, and TBC1D21. Each is linked with GTF2F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2F2-to-partner and partner-to-GTF2F2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2F2→partner) and Y-score (partner→GTF2F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SPIC →	+0.304	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.017	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

GTF2F2 survival (RNA) · tumor vs normal (RNA) · all GTF2F2 data types