GTF2F1

Across TCGA patient cohorts, GTF2F1 mutation is significantly associated with the RNA expression of many other genes, with 3,549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2F1-associated genes across cancer lineages are MRPL32P1, MTCYBP29, and GNPNAT1. Each is linked with GTF2F1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTF2F1-to-partner and partner-to-GTF2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL32P1 grouped by GTF2F1-low versus GTF2F1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2F1→partner) and Y-score (partner→GTF2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MRPL32P1 →	+0.222	+5.474	<.001	.005	3	3
BLCA	MTCYBP29 →	+0.062	+4.320	<.001	.002	3	2
UCEC	GNPNAT1 →	+0.710	+2.534	<.001	<.001	3	2
UCEC	VTI1B →	+0.425	+2.831	<.001	.001	3	2
UCEC	ZC3H14 →	+0.333	+2.021	.005	.001	3	2
UCEC	SRP54 →	+0.443	+2.502	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,549 associations by consensus.

MRPL32P1 by GTF2F1 expression — LUSC

Explore this box plot interactively →