GTF2F1

Across TCGA patient cohorts, GTF2F1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2F1-associated genes across cancer lineages are Di-Ras3, 14-3-3_beta, and EGFR_pY1068. Each is linked with GTF2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2F1-to-partner and partner-to-GTF2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by GTF2F1-low versus GTF2F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2F1→partner) and Y-score (partner→GTF2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.181	-3.446	.001	.005	3	2
UCEC	14-3-3_beta →	-0.115	-2.558	.003	.010	3	1
UCEC	EGFR_pY1068 →	-0.292	-2.502	.003	.002	3	1
UCEC	eIF4G →	+0.343	+2.321	.004	.033	3	1
UCEC	A-Raf_pS299 →	-0.147	-2.584	.001	.010	3	1
UCEC	FoxM1 →	+0.250	+2.000	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Di-Ras3 by GTF2F1 expression — UCEC

Explore this box plot interactively →