GTF2F1

Across TCGA cell cohorts, GTF2F1 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF2F1-associated genes across cancer lineages are LRIT1, TEX46, and OR1D4. Each is linked with GTF2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2F1-to-partner and partner-to-GTF2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by GTF2F1-low versus GTF2F1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2F1→partner) and Y-score (partner→GTF2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRIT1 →	+0.030	+3.684	<.001	.004	3	2
BLOOD_Leukemia	TEX46 →	+0.143	+3.803	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR1D4 →	+0.062	+5.662	<.001	.002	3	2
BLOOD_Leukemia	GML →	+0.088	+3.567	<.001	.003	3	1
BLOOD_Leukemia	C9 →	+1.024	+3.775	<.001	.004	3	1
BLOOD_Leukemia	RAB19 →	+0.470	+3.594	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

LRIT1 by GTF2F1 expression — BLOOD_Leukemia

Explore this box plot interactively →