GTF2F1

Across TCGA cell cohorts, GTF2F1 mutation is significantly associated with the mutation status of many other genes, with 3,485 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2F1-associated genes across cancer lineages are NBEA, ZNF107, and SYNJ2. Each is linked with GTF2F1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GTF2F1-to-partner and partner-to-GTF2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NBEA grouped by GTF2F1-low versus GTF2F1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2F1→partner) and Y-score (partner→GTF2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NBEA →	+3.199	+4.633	.003	.003	1	4
SOFT_TISSUE	ZNF107 →	+5.502	+5.502	.003	.003	1	4
LARGE_INTESTINE	SYNJ2 →	+1.836	+2.906	.009	.009	1	4
CNS	KNL1 →	+3.877	+5.139	.001	.001	1	4
SKIN	TECPR1 →	+3.655	+4.906	.001	.001	1	4
BLOOD_Leukemia	RAI1 →	+2.360	+3.189	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,485 associations by consensus.

NBEA by GTF2F1 expression — CNS

Explore this box plot interactively →