Across TCGA patient cohorts, GTF2E2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2E2-associated genes across cancer lineages are EGFR_pY1068, ERK2, and INPP4B. Each is linked with GTF2E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2E2-to-partner and partner-to-GTF2E2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2E2→partner) and Y-score (partner→GTF2E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.316	-2.700	.005	.006	3	1
UCEC	ERK2 →	+0.256	+2.700	.003	.006	3	1
UCEC	INPP4B →	-0.309	-3.169	.034	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.195	-3.000	.010	.036	3	1
UCEC	JNK2 →	+0.233	+2.000	.009	.032	3	1
UCEC	Mre11 →	-0.083	-2.000	.031	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

GTF2E2 survival (RNA) · tumor vs normal (RNA) · all GTF2E2 data types