Across TCGA cell cohorts, GTF2E2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,102 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF2E2-associated GO terms across cancer lineages are Negative regulation of regulatory ncRNA-mediated heterochromatin formation, Regulation of regulatory ncRNA-mediated heterochromatin formation, and piRNA-mediated gene silencing by mRNA destabilization. Each is linked with GTF2E2 in more than 12 cancer types. Because this analysis shows association rather than direction, both GTF2E2-to-partner and partner-to-GTF2E2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2E2→partner) and Y-score (partner→GTF2E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.131	+0.768	.001	.004	3	13
BONE	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.131	+0.768	.001	.004	3	13
LUNG_SCLC	piRNA-mediated gene silencing by mRNA destabilization →	+0.190	+0.612	.001	.003	3	11
BREAST	Interkinetic nuclear migration →	+0.121	+1.002	<.001	<.001	3	9
BREAST	snRNA metabolic process →	+0.065	+0.658	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Purine deoxyribonucleoside diphosphate metabolic process →	-0.110	-0.835	.005	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,102 associations by consensus.

Exploration

GTF2E2 survival (RNA) · tumor vs normal (RNA) · all GTF2E2 data types