GTF2E1

Across TCGA patient cohorts, GTF2E1 mutation is significantly associated with the RNA expression of many other genes, with 1,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2E1-associated genes across cancer lineages are MIR1305, MIR5693, and MIR8070. Each is linked with GTF2E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2E1-to-partner and partner-to-GTF2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1305 grouped by GTF2E1-low versus GTF2E1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2E1→partner) and Y-score (partner→GTF2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR1305 →	+0.667	+6.059	<.001	<.001	3	2
LUSC	MIR5693 →	+0.704	+4.884	<.001	.002	3	2
BLCA	MIR8070 →	+0.678	+3.623	<.001	.004	3	2
UCEC	SAP30 →	+0.630	+3.633	.001	.001	3	2
UCEC	MRM3 →	+0.426	+3.343	.002	.005	3	2
UCEC	TIMM22 →	+0.461	+3.141	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

MIR1305 by GTF2E1 expression — LUSC

Explore this box plot interactively →