GTF2E1

Across TCGA patient cohorts, GTF2E1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2E1-associated genes across cancer lineages are Ku80, cIAP, and Cyclin-B1. Each is linked with GTF2E1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTF2E1-to-partner and partner-to-GTF2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GTF2E1-low versus GTF2E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2E1→partner) and Y-score (partner→GTF2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.296	+2.713	.005	.003	3	2
UCEC	cIAP →	+0.139	+3.179	.025	.010	3	2
UCEC	Cyclin-B1 →	+0.616	+2.000	.014	.032	2	3
UCEC	FASN →	+0.430	+3.807	.015	<.001	3	1
UCEC	ACVRL1 →	-0.160	-2.986	.009	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.687	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Ku80 by GTF2E1 expression — UCEC

Explore this box plot interactively →