GTF2A2

Across TCGA patient cohorts, GTF2A2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GTF2A2-associated genes across cancer lineages are MIR6715A, MIR4498, and SNORA25B. Each is linked with GTF2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2A2-to-partner and partner-to-GTF2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6715A grouped by GTF2A2-low versus GTF2A2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2A2→partner) and Y-score (partner→GTF2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6715A →	+0.461	+7.731	<.001	.009	3	1
BRCA	MIR4498 →	+0.467	+8.055	<.001	.007	3	1
BRCA	SNORA25B →	+0.315	+7.731	<.001	.009	3	1
BRCA	SEPTIN14P3 →	+0.208	+7.731	<.001	.009	3	1
BRCA	ZNF886P →	+0.069	+8.471	<.001	.005	3	1
UCEC	RNU6-992P →	+0.304	+5.292	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MIR6715A by GTF2A2 expression — BRCA

Explore this box plot interactively →