GTF2A1

Across TCGA pan-cancer cohorts, GTF2A1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GTF2A1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GTF2A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GTF2A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and LSCC are the cancer types where GTF2A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.689	0.369	.009	14	view →
COAD	DFS	Median	All	1.000	0.874	.023	12	view →
LSCC	DFS	Median	III,IV	0.909	0.468	.009	12	view →
GBM	OS	Quartile	All	0.546	0.266	.022	6	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	4	view →
UCEC	DFS	Quartile	All	1.000	0.814	.038	2	view →
CCRCC	OS	Median	All	1.000	0.700	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GTF2A1–PDAC (OS)

Open the PDAC breakdown →