GTF2A1

Across TCGA patient cohorts, GTF2A1 mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2A1-associated genes across cancer lineages are RNU6-258P, IQCF5, and MIR4695. Each is linked with GTF2A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTF2A1-to-partner and partner-to-GTF2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-258P grouped by GTF2A1-low versus GTF2A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2A1→partner) and Y-score (partner→GTF2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-258P →	+0.262	+4.257	<.001	.007	3	3
LUSC	IQCF5 →	+0.045	+4.780	.006	.003	3	3
LUSC	MIR4695 →	+0.261	+4.116	<.001	.009	3	2
SKCM	MIR4279 →	+0.327	+7.816	<.001	.008	3	2
UCEC	ADGRL3 →	+0.957	+3.345	.002	.005	3	1
UCEC	CCDC3 →	-1.046	-3.584	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

RNU6-258P by GTF2A1 expression — LUSC

Explore this box plot interactively →