GTF2A1

Across TCGA patient cohorts, GTF2A1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTF2A1-associated genes across cancer lineages are EGFR_pY1173, FOXO3a_pS318_S321, and Acetyl-a-Tubulin-Lys40. Each is linked with GTF2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2A1-to-partner and partner-to-GTF2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by GTF2A1-low versus GTF2A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2A1→partner) and Y-score (partner→GTF2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.104	+2.196	.013	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-3.160	.026	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.628	+3.321	.018	.010	3	1
UCEC	VHL →	-0.979	-3.169	.005	.019	3	1
UCEC	4E-BP1 →	+0.464	+2.837	.001	.035	3	1
UCEC	Shc_pY317 →	-0.213	-3.321	.007	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1173 by GTF2A1 expression — UCEC

Explore this box plot interactively →