GTF2A1

Across TCGA cell cohorts, GTF2A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,199 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GTF2A1-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Mitotic nuclear division, and Protein localization to chromosome. Each is linked with GTF2A1 in more than 15 cancer types. Because this analysis shows association rather than direction, both GTF2A1-to-partner and partner-to-GTF2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by GTF2A1-low versus GTF2A1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2A1→partner) and Y-score (partner→GTF2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Double-strand break repair via nonhomologous end joining →	+0.057	+1.038	<.001	<.001	3	16
LUNG_SCLC	Mitotic nuclear division →	+0.072	+0.673	.001	.002	3	15
KIDNEY	Protein localization to chromosome →	+0.089	+1.025	<.001	<.001	3	15
KIDNEY	Positive regulation of cell cycle →	+0.070	+0.783	<.001	<.001	3	15
BLOOD_Myeloma	Spindle assembly →	+0.101	+1.146	<.001	.004	3	15
KIDNEY	Mitotic sister chromatid segregation →	+0.074	+0.831	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,199 associations by consensus.

Double-strand break repair via nonhomologous end joining by GTF2A1 expression — BREAST

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