GTF2A1

Across TCGA cell cohorts, GTF2A1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTF2A1-associated genes across cancer lineages are C1orf185, CXorf51A, and MSGN1. Each is linked with GTF2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTF2A1-to-partner and partner-to-GTF2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf185 grouped by GTF2A1-low versus GTF2A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2A1→partner) and Y-score (partner→GTF2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1orf185 →	+0.063	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.062	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	INSL5 →	+0.290	+3.626	<.001	.006	3	1
LARGE_INTESTINE	TFDP3 →	+0.031	+3.196	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C1orf185 by GTF2A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →