GTDC1

Across TCGA pan-cancer cohorts, GTDC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GTDC1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GTDC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTDC1 expression acts as an unfavorable survival marker.

LSCC, HNSC, and PDAC are the cancer types where GTDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.454	0.923	<.001	26	view →
HNSC	DFS	Quartile	All	0.571	0.904	.003	18	view →
PDAC	DFS	Median	III,IV	0.493	0.998	.020	4	view →
CCRCC	OS	Tertile	IV	0.125	0.789	.036	3	view →
UCEC	DFS	Median	All	0.946	1.000	.037	2	view →
LUAD	OS	Quartile	II,III,IV	0.441	0.762	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GTDC1–LSCC (DFS)

Open the LSCC breakdown →