GTDC1

Across TCGA patient cohorts, GTDC1 mutation is significantly associated with the RNA expression of many other genes, with 3,356 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GTDC1-associated genes across cancer lineages are RPS10P21, ESS2, and CCT5. Each is linked with GTDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GTDC1-to-partner and partner-to-GTDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10P21 grouped by GTDC1-low versus GTDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTDC1→partner) and Y-score (partner→GTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS10P21 →	+0.267	+1.922	<.001	<.001	3	3
UCEC	ESS2 →	+0.248	+1.788	.002	.001	3	3
UCEC	CCT5 →	+0.492	+2.069	.002	<.001	3	3
UCEC	MVD →	+0.722	+4.302	<.001	<.001	3	3
SKCM	FANCG →	+0.724	+3.214	<.001	.009	3	3
UCEC	BCL2L2-PABPN1 →	+0.239	+2.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,356 associations by consensus.

RPS10P21 by GTDC1 expression — UCEC

Explore this box plot interactively →