GTDC1

Across TCGA cell cohorts, GTDC1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GTDC1-associated genes across cancer lineages are MS4A10, FAM236A, and TKTL2. Each is linked with GTDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GTDC1-to-partner and partner-to-GTDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by GTDC1-low versus GTDC1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTDC1→partner) and Y-score (partner→GTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.059	+4.509	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MS4A10 by GTDC1 expression — OVARY

Explore this box plot interactively →