GSX2

Across TCGA patient cohorts, GSX2 mutation is significantly associated with the RNA expression of many other genes, with 2,500 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSX2-associated genes across cancer lineages are XRCC6, PPP2R2A, and NEIL2. Each is linked with GSX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GSX2-to-partner and partner-to-GSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XRCC6 grouped by GSX2-low versus GSX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSX2→partner) and Y-score (partner→GSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XRCC6 →	+0.642	+3.191	<.001	<.001	3	3
UCEC	PPP2R2A →	+0.626	+3.354	<.001	.005	3	3
UCEC	NEIL2 →	+0.614	+3.169	.001	<.001	3	3
UCEC	BUB1B →	+0.793	+2.708	.001	.003	3	3
UCEC	PSMA4 →	+0.451	+3.716	.003	<.001	3	3
UCEC	TRMU →	+0.515	+2.839	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,500 associations by consensus.

XRCC6 by GSX2 expression — UCEC

Explore this box plot interactively →