GSX2

Across TCGA patient cohorts, GSX2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSX2-associated genes across cancer lineages are A-Raf_pS299, MEK1, and Notch1. Each is linked with GSX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GSX2-to-partner and partner-to-GSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by GSX2-low versus GSX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSX2→partner) and Y-score (partner→GSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	A-Raf_pS299 →	-0.246	-2.991	.005	.036	3	2
UCEC	MEK1 →	+0.515	+3.087	<.001	<.001	3	2
COAD	Notch1 →	+0.258	+3.008	.007	.019	2	3
UCEC	eIF4E →	+0.182	+1.906	.032	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.632	+2.720	.008	.003	3	2
UCEC	Di-Ras3 →	-0.160	-3.446	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

A-Raf_pS299 by GSX2 expression — COAD

Explore this box plot interactively →