GSX1

Across TCGA patient cohorts, GSX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,753 significant associations in total. LGG shows the largest number of these associations.

The most reproducible GSX1-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via nonhomologous end joining, Negative regulation of DNA binding, and Neuron projection organization. Each is linked with GSX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both GSX1-to-partner and partner-to-GSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via nonhomologous end joining grouped by GSX1-low versus GSX1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSX1→partner) and Y-score (partner→GSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of double-strand break repair via nonhomologous end joining →	+0.062	+0.261	<.001	.002	3	10
STAD	Negative regulation of DNA binding →	+0.043	+0.152	<.001	.001	3	7
STAD	Neuron projection organization →	+0.043	+0.164	<.001	<.001	3	6
ESCA	Spliceosomal snRNP assembly →	+0.042	+0.049	<.001	<.001	3	6
STAD	Base-excision repair →	+0.059	+0.145	<.001	.002	2	7
STAD	Anterior/posterior pattern specification →	+0.042	+0.203	<.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,753 associations by consensus.

Positive regulation of double-strand break repair via nonhomologous end joining by GSX1 expression — STAD

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