GSX1

Across TCGA cell cohorts, GSX1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GSX1-associated genes across cancer lineages are TMIGD3, PRAMEF10, and LORICRIN. Each is linked with GSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSX1-to-partner and partner-to-GSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMIGD3 grouped by GSX1-low versus GSX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSX1→partner) and Y-score (partner→GSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMIGD3 →	+0.614	+4.817	<.001	.001	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	LORICRIN →	+0.043	+4.817	<.001	.001	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TMIGD3 by GSX1 expression — LUNG_SCLC

Explore this box plot interactively →