GSTZ1

Across TCGA patient cohorts, GSTZ1 mutation is significantly associated with the RNA expression of many other genes, with 1,467 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTZ1-associated genes across cancer lineages are ATP5PFP1, MTCYBP8, and KRTAP2-5P. Each is linked with GSTZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTZ1-to-partner and partner-to-GSTZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5PFP1 grouped by GSTZ1-low versus GSTZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTZ1→partner) and Y-score (partner→GSTZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5PFP1 →	+0.358	+2.250	.003	.006	3	2
HNSC	MTCYBP8 →	+0.069	+5.822	<.001	.003	3	1
HNSC	KRTAP2-5P →	+0.118	+7.132	<.001	<.001	3	1
HNSC	RN7SKP82 →	+0.206	+6.936	<.001	<.001	3	1
HNSC	RNU6-1191P →	+0.347	+6.008	<.001	.002	3	1
HNSC	LRRC6P1 →	+0.052	+5.822	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

ATP5PFP1 by GSTZ1 expression — UCEC

Explore this box plot interactively →