GSTZ1

Across TCGA patient cohorts, GSTZ1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTZ1-associated genes across cancer lineages are ATM, 4E-BP1, and EGFR_pY1068. Each is linked with GSTZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTZ1-to-partner and partner-to-GSTZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GSTZ1-low versus GSTZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTZ1→partner) and Y-score (partner→GSTZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.409	-2.000	.045	.032	3	2
UCEC	4E-BP1 →	+0.394	+3.029	.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.223	-2.000	.049	.032	3	1
UCEC	mTOR_pS2448 →	-0.163	-3.308	.015	.009	3	1
UCEC	p38-MAPK →	-0.209	-2.986	.004	.035	3	1
UCEC	p62 Lck ligand →	+0.328	+2.700	.025	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by GSTZ1 expression — UCEC

Explore this box plot interactively →