GSTZ1

Across TCGA cell cohorts, GSTZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,403 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GSTZ1-associated GO terms across cancer lineages are L-phenylalanine metabolic process, L-phenylalanine catabolic process, and Aromatic amino acid metabolic process. Each is linked with GSTZ1 in more than 15 cancer types. Because this analysis shows association rather than direction, both GSTZ1-to-partner and partner-to-GSTZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-phenylalanine metabolic process grouped by GSTZ1-low versus GSTZ1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTZ1→partner) and Y-score (partner→GSTZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	L-phenylalanine metabolic process →	+0.346	+1.086	<.001	<.001	3	16
URINARY_TRACT	L-phenylalanine catabolic process →	+0.555	+1.237	.003	<.001	3	12
URINARY_TRACT	Aromatic amino acid metabolic process →	+0.144	+1.023	.009	.003	3	9
LUNG_NSCLC_LUSC	Aromatic amino acid family catabolic process →	+0.238	+1.051	.009	.009	2	10
LUNG_SCLC	Oxidative RNA demethylation →	+0.083	+0.697	.002	.003	3	8
LARGE_INTESTINE	Mitochondrial proton-transporting ATP synthase complex assembly →	+0.091	+0.733	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,403 associations by consensus.

L-phenylalanine metabolic process by GSTZ1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →