GSTM5

Across TCGA patient cohorts, GSTM5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTM5-associated genes across cancer lineages are JNK2, mTOR_pS2448, and ASNS. Each is linked with GSTM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTM5-to-partner and partner-to-GSTM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by GSTM5-low versus GSTM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM5→partner) and Y-score (partner→GSTM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.211	+1.807	.010	.027	3	2
UCEC	mTOR_pS2448 →	-0.197	-3.680	.001	.001	3	2
UCEC	ASNS →	+0.686	+3.000	<.001	.001	3	2
UCEC	C-Raf_pS338 →	-0.104	-3.295	.001	.009	3	2
UCEC	Cyclin-E2 →	+0.151	+3.331	.029	.005	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.573	+2.222	.013	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

JNK2 by GSTM5 expression — UCEC

Explore this box plot interactively →