GSTM5

Across TCGA cell cohorts, GSTM5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GSTM5-associated genes across cancer lineages are ZAN and SMIM23. Each is linked with GSTM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTM5-to-partner and partner-to-GSTM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by GSTM5-low versus GSTM5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM5→partner) and Y-score (partner→GSTM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZAN →	+0.006	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	SMIM23 →	+0.637	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ZAN by GSTM5 expression — URINARY_TRACT

Explore this box plot interactively →