GSTM3

Across TCGA patient cohorts, GSTM3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTM3-associated genes across cancer lineages are p27_pT198, Rab11, and Caspase-8. Each is linked with GSTM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTM3-to-partner and partner-to-GSTM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by GSTM3-low versus GSTM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM3→partner) and Y-score (partner→GSTM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.116	+3.459	.030	.005	3	1
UCEC	Rab11 →	-0.152	-2.321	.037	.035	3	1
UCEC	Caspase-8 →	-0.362	-3.459	.004	.005	3	1
UCEC	ER-alpha_pS118 →	+0.432	+3.000	.016	.036	2	1
UCEC	VHL →	-1.255	-3.169	<.001	.019	2	1
UCEC	Cyclin-B1 →	+0.566	+2.321	.044	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p27_pT198 by GSTM3 expression — UCEC

Explore this box plot interactively →