GSTM3

Across TCGA cell cohorts, GSTM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,572 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSTM3-associated GO terms across cancer lineages are Nitrobenzene metabolic process, Xenobiotic catabolic process, and Benzene-containing compound metabolic process. Each is linked with GSTM3 in more than 17 cancer types. Because this analysis shows association rather than direction, both GSTM3-to-partner and partner-to-GSTM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nitrobenzene metabolic process grouped by GSTM3-low versus GSTM3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM3→partner) and Y-score (partner→GSTM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nitrobenzene metabolic process →	+1.598	+3.823	<.001	<.001	3	18
LUNG_SCLC	Xenobiotic catabolic process →	+0.199	+2.025	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Benzene-containing compound metabolic process →	+0.211	+3.911	<.001	<.001	3	12
BLOOD_Lymphoma	Purine ribonucleotide biosynthetic process →	+0.070	+0.564	<.001	.002	3	11
OESOPHAGUS	Ribose phosphate biosynthetic process →	+0.068	+3.609	.006	.007	3	11
SKIN	Purine ribonucleoside triphosphate metabolic process →	+0.064	+2.359	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

Nitrobenzene metabolic process by GSTM3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →