Across TCGA patient cohorts, GSTM2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSTM2-associated genes across cancer lineages are 4E-BP1, JNK2, and Notch1. Each is linked with GSTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSTM2-to-partner and partner-to-GSTM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM2→partner) and Y-score (partner→GSTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.347	+2.837	.014	.035	3	1
UCEC	JNK2 →	+0.360	+3.321	<.001	.010	1	2
UCEC	Notch1 →	+0.153	+2.817	.038	.036	2	1
UCEC	Shc_pY317 →	-0.228	-3.000	.004	.036	2	1
UCEC	Stathmin →	+0.152	+3.321	.035	.010	1	2
UCEC	PDCD4 →	-0.877	-3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

GSTM2 survival (RNA) · tumor vs normal (RNA) · all GSTM2 data types