GSTM1

Across TCGA pan-cancer cohorts, GSTM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GSTM1 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GSTM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GSTM1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where GSTM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.357	1.000	.005	34	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.152	.002	19	view →
CCRCC	DFS	Quartile	III,IV	0.954	0.480	.001	15	view →
PDAC	OS	Tertile	III,IV	0.226	0.717	.024	9	view →
GBM	OS	Tertile	All	0.340	0.557	.009	5	view →
LSCC	DFS	Median	All	0.828	0.624	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GSTM1–UCEC (DFS)

Open the UCEC breakdown →