GSTM1

Across TCGA patient cohorts, GSTM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,097 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible GSTM1-associated GO terms across cancer lineages are Detoxification of nitrogen compound, Benzene-containing compound metabolic process, and Long-chain fatty acid biosynthetic process. Each is linked with GSTM1 in more than 31 cancer types. Because this analysis shows association rather than direction, both GSTM1-to-partner and partner-to-GSTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Detoxification of nitrogen compound grouped by GSTM1-low versus GSTM1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSTM1→partner) and Y-score (partner→GSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Detoxification of nitrogen compound →	+0.119	+1.778	<.001	<.001	3	32
UVM	Benzene-containing compound metabolic process →	+0.075	+3.002	<.001	<.001	2	29
UCS	Long-chain fatty acid biosynthetic process →	+0.055	+1.962	<.001	.001	2	28
SCLC	Xenobiotic catabolic process →	+0.177	+2.362	.001	.002	1	25
ACC	Hepoxilin metabolic process →	+0.092	+3.972	<.001	<.001	3	20
LAML	Glutathione metabolic process →	+0.031	+1.825	.001	.003	1	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,097 associations by consensus.

Detoxification of nitrogen compound by GSTM1 expression — LAML

Explore this box plot interactively →