GSS

Across TCGA patient cohorts, GSS protein abundance is significantly associated with the RNA expression of many other genes, with 13,564 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GSS-associated genes across cancer lineages are ACSS2, MAP4K3-DT, and TEAD2. Each is linked with GSS in more than 4 cancer types. Because this analysis shows association rather than direction, both GSS-to-partner and partner-to-GSS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSS versus ACSS2 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSS→partner) and Y-score (partner→GSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACSS2 →	+0.627	+0.482	<.001	<.001	3	5
UCEC	MAP4K3-DT →	+0.398	+0.252	<.001	.001	3	4
BRCA	TEAD2 →	-0.905	-0.389	<.001	.004	3	4
BRCA	HJURP →	-1.057	-0.528	<.001	<.001	3	4
BRCA	NASP →	-0.636	-0.547	<.001	<.001	3	4
GBM	KIF23 →	-0.817	-0.238	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,564 associations by consensus.

GSS vs ACSS2 — BRCA

Explore this scatter interactively →