GSS

Across TCGA cell cohorts, GSS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,603 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSS-associated GO terms across cancer lineages are Regulation of centriole-centriole cohesion, Negative regulation of t-circle formation, and Regulation of telomeric loop disassembly. Each is linked with GSS in more than 10 cancer types. Because this analysis shows association rather than direction, both GSS-to-partner and partner-to-GSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole-centriole cohesion grouped by GSS-low versus GSS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSS→partner) and Y-score (partner→GSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of centriole-centriole cohesion →	+0.162	+0.511	.001	.001	1	11
SOFT_TISSUE	Negative regulation of t-circle formation →	+0.106	+0.557	.001	<.001	3	9
SOFT_TISSUE	Regulation of telomeric loop disassembly →	+0.079	+0.409	.007	.007	2	10
SOFT_TISSUE	Regulation of telomere capping →	+0.092	+0.659	<.001	<.001	3	8
KIDNEY	Negative regulation of DNA metabolic process →	+0.044	+0.720	.001	<.001	3	8
STOMACH	Positive regulation of cell cycle checkpoint →	+0.087	+0.983	.006	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,603 associations by consensus.

Regulation of centriole-centriole cohesion by GSS expression — OESOPHAGUS

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