GSR

Across TCGA patient cohorts, GSR protein abundance is significantly associated with the RNA expression of many other genes, with 13,766 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GSR-associated genes across cancer lineages are SH2D4A, DMTN, and TRIM35. Each is linked with GSR in more than 7 cancer types. Because this analysis shows association rather than direction, both GSR-to-partner and partner-to-GSR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSR versus SH2D4A in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSR→partner) and Y-score (partner→GSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D4A →	+0.788	+0.433	<.001	<.001	3	8
OV	DMTN →	+1.098	+0.418	<.001	<.001	3	8
UCEC	TRIM35 →	+0.582	+0.405	<.001	<.001	3	7
BRCA	UBXN8 →	+0.698	+0.484	<.001	<.001	3	7
OV	PPP2CB →	+0.631	+0.474	<.001	<.001	3	7
BRCA	MTUS1 →	+0.866	+0.355	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,766 associations by consensus.

GSR vs SH2D4A — BRCA

Explore this scatter interactively →