GSR

Across TCGA patient cohorts, GSR mutation is significantly associated with the RNA expression of many other genes, with 2,771 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSR-associated genes across cancer lineages are DUX4L46, MIR4314, and MIR3171. Each is linked with GSR in more than 1 cancer types. Because this analysis shows association rather than direction, both GSR-to-partner and partner-to-GSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUX4L46 grouped by GSR-low versus GSR-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSR→partner) and Y-score (partner→GSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DUX4L46 →	+0.093	+5.688	<.001	<.001	3	2
LUAD	MIR4314 →	+0.209	+4.584	<.001	.005	3	2
COAD	MIR3171 →	+0.793	+7.741	<.001	.009	3	2
CESC	FAM96AP1 →	+0.089	+6.584	<.001	<.001	3	1
CESC	NF1P8 →	+0.496	+4.320	.009	.007	3	1
CESC	NIFKP9 →	+0.190	+4.669	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,771 associations by consensus.

DUX4L46 by GSR expression — CESC

Explore this box plot interactively →