GSR

Across TCGA patient cohorts, GSR mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSR-associated genes across cancer lineages are Ku80, eIF4G, and FASN. Each is linked with GSR in more than 1 cancer types. Because this analysis shows association rather than direction, both GSR-to-partner and partner-to-GSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GSR-low versus GSR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSR→partner) and Y-score (partner→GSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.209	+1.375	.012	.024	3	2
UCEC	eIF4G →	+0.216	+1.807	.048	.025	3	1
UCEC	FASN →	+0.397	+2.321	.004	.033	3	1
UCEC	FOXO3a_pS318_S321 →	-0.093	-1.896	.035	.015	3	1
UCEC	ACC_pS79 →	+0.282	+2.000	.021	.029	3	1
UCEC	ACC1 →	+0.333	+3.472	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Ku80 by GSR expression — UCEC

Explore this box plot interactively →