GSR

Across TCGA cell cohorts, GSR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,731 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GSR-associated GO terms across cancer lineages are DNA replication-dependent chromatin assembly, Regulation of protein processing, and Regulation of protein maturation. Each is linked with GSR in more than 11 cancer types. Because this analysis shows association rather than direction, both GSR-to-partner and partner-to-GSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication-dependent chromatin assembly grouped by GSR-low versus GSR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSR→partner) and Y-score (partner→GSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication-dependent chromatin assembly →	+0.150	+1.797	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of protein processing →	-0.166	-1.484	.001	.004	3	11
BONE	Regulation of protein maturation →	-0.213	-0.777	<.001	.006	2	12
LIVER	GABAergic neuron differentiation →	-1.100	-1.653	.007	.001	3	11
URINARY_TRACT	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.127	+1.033	<.001	.002	3	10
URINARY_TRACT	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.127	+1.033	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

DNA replication-dependent chromatin assembly by GSR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →