GSPT1

Across TCGA patient cohorts, GSPT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,699 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GSPT1-associated proteins across cancer lineages are USP7, PARN, and DCTPP1. Each is linked with GSPT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSPT1 versus USP7 in LSCC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP7 →	+0.201	+0.415	<.001	<.001	3	6
CCRCC	PARN →	+0.277	+0.384	<.001	<.001	3	6
LSCC	DCTPP1 →	+0.611	+0.467	<.001	<.001	3	6
CCRCC	ETF1 →	+0.265	+0.328	<.001	<.001	3	5
LSCC	THEMIS2 →	-0.492	-0.347	<.001	<.001	3	4
LSCC	RUVBL2 →	+0.254	+0.286	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,699 associations by consensus.

GSPT1 vs USP7 — LSCC

Explore this scatter interactively →