GSPT1

Across TCGA patient cohorts, GSPT1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,352 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GSPT1-associated genes across cancer lineages are PTGIR, ANGPTL2, and DIPK2B. Each is linked with GSPT1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSPT1 versus PTGIR in CCRCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTGIR →	-0.771	-0.184	<.001	<.001	3	8
OV	ANGPTL2 →	-1.221	-0.263	.001	.004	3	7
CCRCC	DIPK2B →	-1.063	-0.204	<.001	<.001	3	7
OV	POLR3K →	+0.578	+0.236	<.001	.001	3	7
OV	GEM →	-1.286	-0.318	<.001	<.001	3	7
OV	HEG1 →	-1.116	-0.227	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,352 associations by consensus.

GSPT1 vs PTGIR — CCRCC

Explore this scatter interactively →