GSPT1

Across TCGA patient cohorts, GSPT1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSPT1-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and Src_pY416. Each is linked with GSPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GSPT1-low versus GSPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.294	+3.335	.017	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.573	-3.308	.015	.010	3	1
UCEC	Src_pY416 →	-0.261	-3.308	.039	.010	3	1
UCEC	Cyclin-E2 →	+0.182	+2.817	.039	.036	3	1
UCEC	FoxM1 →	+0.346	+3.321	.010	.010	2	1
UCEC	PCNA →	+0.310	+3.321	.006	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by GSPT1 expression — UCEC

Explore this box plot interactively →