GSPT1

Across TCGA cell cohorts, GSPT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,831 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSPT1-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Telomerase RNA stabilization, and Protein localization to condensed chromosome. Each is linked with GSPT1 in more than 13 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by GSPT1-low versus GSPT1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Symbiont-mediated disruption of host cell PML body →	+0.154	+1.055	<.001	<.001	3	14
LIVER	Telomerase RNA stabilization →	+0.130	+0.881	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to condensed chromosome →	+0.155	+1.068	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.218	+1.098	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.172	+1.006	<.001	<.001	3	13
BLOOD_Myeloma	Positive regulation of mRNA processing →	+0.111	+0.705	.006	.008	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,831 associations by consensus.

Symbiont-mediated disruption of host cell PML body by GSPT1 expression — LIVER

Explore this box plot interactively →