GSPT1

Across TCGA cell cohorts, GSPT1 mutation is significantly associated with the RNA expression of many other genes, with 223 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSPT1-associated genes across cancer lineages are DESI1, GPR63, and PCCB. Each is linked with GSPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by GSPT1-low versus GSPT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.551	+3.169	<.001	.009	3	1
LARGE_INTESTINE	GPR63 →	+0.871	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PCCB →	+0.601	+3.451	.001	.002	3	1
LARGE_INTESTINE	KDSR →	+0.814	+3.364	.001	.002	3	1
LARGE_INTESTINE	NCLN →	+0.496	+3.067	.001	.009	3	1
LARGE_INTESTINE	ELP2 →	+0.698	+3.169	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

DESI1 by GSPT1 expression — LARGE_INTESTINE

Explore this box plot interactively →