GSKIP

Across TCGA pan-cancer cohorts, GSKIP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GSKIP’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GSKIP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GSKIP is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where GSKIP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSKIP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.603	<.001	9	view →
LSCC	Male	II,III,IV	+0.442	<.001	9	view →
HNSC	Male	III,IV	−0.311	<.001	8	view →
COAD	All	II,III,IV	−0.166	.002	8	view →
PDAC	Male	All	+0.705	<.001	6	view →
CCRCC	All	III,IV	+0.102	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GSKIP–LUAD

Open the LUAD breakdown →