GSK3B

Across TCGA patient cohorts, GSK3B protein abundance is significantly associated with the RNA expression of many other genes, with 16,863 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GSK3B-associated genes across cancer lineages are UMPS, TIMMDC1, and SEC22A. Each is linked with GSK3B in more than 6 cancer types. Because this analysis shows association rather than direction, both GSK3B-to-partner and partner-to-GSK3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GSK3B versus UMPS in LSCC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3B→partner) and Y-score (partner→GSK3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UMPS →	+0.523	+0.293	<.001	<.001	3	7
OV	TIMMDC1 →	+0.487	+0.298	<.001	<.001	3	7
CCRCC	SEC22A →	+0.449	+0.258	<.001	<.001	3	7
LSCC	KDM5B →	+0.486	+0.210	<.001	<.001	3	6
LSCC	CSF3R →	-0.855	-0.236	<.001	.003	3	6
PDAC	ADGRE3 →	-0.791	-0.364	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,863 associations by consensus.

GSK3B vs UMPS — LSCC

Explore this scatter interactively →