GSK3B

Across TCGA patient cohorts, GSK3B mutation is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSK3B-associated genes across cancer lineages are TIMM22, MSANTD3, and CRYBB2P1. Each is linked with GSK3B in more than 2 cancer types. Because this analysis shows association rather than direction, both GSK3B-to-partner and partner-to-GSK3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM22 grouped by GSK3B-low versus GSK3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3B→partner) and Y-score (partner→GSK3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM22 →	+0.539	+3.860	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.704	+2.711	<.001	.003	3	3
UCEC	CRYBB2P1 →	+0.652	+3.523	<.001	.002	3	2
UCEC	MCAT →	+0.415	+3.330	.009	.005	3	2
UCEC	MCM5 →	+0.621	+3.346	.006	.005	3	2
UCEC	CDKN3 →	+0.821	+3.467	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

TIMM22 by GSK3B expression — UCEC

Explore this box plot interactively →