GSK3B

Across TCGA patient cohorts, GSK3B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSK3B-associated genes across cancer lineages are C-Raf, p62 Lck ligand, and PDCD4. Each is linked with GSK3B in more than 1 cancer types. Because this analysis shows association rather than direction, both GSK3B-to-partner and partner-to-GSK3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by GSK3B-low versus GSK3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3B→partner) and Y-score (partner→GSK3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.203	+2.321	.004	.035	3	2
UCEC	p62 Lck ligand →	+0.417	+2.817	.010	.036	3	1
UCEC	PDCD4 →	-0.777	-2.321	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.510	-2.321	<.001	.035	3	1
UCEC	Tuberin →	+0.473	+2.179	<.001	.034	3	1
UCEC	BRD4 →	+0.287	+2.999	.032	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C-Raf by GSK3B expression — UCEC

Explore this box plot interactively →