GSK3B

Across TCGA cell cohorts, GSK3B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GSK3B-associated GO terms across cancer lineages are Negative regulation of dopaminergic neuron differentiation, Regulation of type B pancreatic cell development, and Regulation of glycogen (starch) synthase activity. Each is linked with GSK3B in more than 16 cancer types. Because this analysis shows association rather than direction, both GSK3B-to-partner and partner-to-GSK3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dopaminergic neuron differentiation grouped by GSK3B-low versus GSK3B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GSK3B→partner) and Y-score (partner→GSK3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of dopaminergic neuron differentiation →	+0.268	+1.044	<.001	<.001	3	17
BONE	Regulation of type B pancreatic cell development →	+0.172	+0.707	.001	.002	3	17
OVARY	Regulation of glycogen (starch) synthase activity →	+0.327	+0.908	.006	<.001	3	16
LIVER	Response to interleukin-3 →	+0.226	+0.772	.004	.002	2	17
LIVER	Cellular response to interleukin-3 →	+0.226	+0.772	.004	.002	2	17
STOMACH	Endosomal transport →	+0.075	+0.843	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,120 associations by consensus.

Negative regulation of dopaminergic neuron differentiation by GSK3B expression — LUNG_SCLC

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